Peer Reviewed Publications
Raschke, M., Bürkle, L., Müller, N., Nunes-Nesi, A., Fernie, A.R., Arigoni, D., Amrhein, N., Fitzpatrick, T.B. Vitamin B1 biosynthesis in plants requires the essential iron sulfur cluster protein, THIC (2007) Proceedings of the National Academy of Sciences U.S.A., 104, 19637-19642
Fitzpatrick, T.B., Amrhein, N., Kappes, B., Macheroux, P., Tews, I., Raschle, T. Two independent routes of de novo vitamin B6 biosynthesis: Not that different after all (2007) The Biochemical Journal, 407, 1-13
Tambasco-Studart, M., Tews, I., Amrhein, N., Fitzpatrick, T.B. Functional analysis of PDX2 from Arabidopsis, a glutaminase involved in vitamin B6 biosynthesis (2007) Plant Physiology, 144, 915-925
Raschle, T., Arigoni, D., Brunisholz, R., Rechsteiner, H., Amrhein, N. & Fitzpatrick, T.B. Reaction mechanism of pyridoxal 5'-phosphate synthase:Detection of an enzyme bound chromophoric intermediate (2007) Journal of Biological Chemistry, 282, 6098-6105
Strohmeier, M., Raschle, T., Mazurkiewicz, J., Rippe, K., Sinning, I., Fitzpatrick, T.B. & Tews, I. Structure of a bacterial pyridoxal 5'-phosphate synthase complex (2006) Proceedings of the National Academy of Sciences U.S.A., 103, 19284-19289
Titiz,O., Tambasco-Studart, M., Warzych, E., Apel, K., Amrhein, N., Laloi, C. & Fitzpatrick, T.B. PDX1 is essential for vitamin B6biosynthesis, development and stress tolerance in Arabidopsis (2006) The Plant Journal, 48, 933-946
Gengenbacher, M., Fitzpatrick, T.B., Raschle, T., Flicker, K., Sinning, I., Muller, S., Macheroux, P., Tews, I. & Kappes, B. Vitamin B6 biosynthesis by the malaria parasite Plasmodium falciparum: Biochemical and structural insights (2006) Journal of Biological Chemistry, 281, 3633-3641
Morokutti, A., Lyskowski, A., Sollner, S., Pointner, E., Fitzpatrick, T.B., Kratky, C., Gruber, K. & Macheroux, P. Structure and function of YcnD from Bacillus subtilis, a flavin containing oxidoreductase (2005) Biochemistry, 44, 13724-13733
Tambasco-Studart, M., Titiz, O., Raschle, T., Forster, G., Amrhein, N. & Fitzpatrick, T.B. Vitamin B6 biosynthesis in higher plants (2005) Proceedings of the National Academy of Sciences U.S.A., 102, 13687-13692
Raschle, T., Amrhein, N. & Fitzpatrick, T.B. On the two components of pyridoxal 5'-phosphate synthase from Bacillus subtilis (2005) Journal of Biological Chemistry, 280, 32291-322300
Kitzing, K., Fitzpatrick, T.B.,Wilken, C., Sawa, J., Bourenkov, G.P., Macheroux, P. & Clausen, T. The 1.3 Å crystal structure of the flavoprotein YqjM reveals a novel class of old yellow enzymes (2005) Journal of Biological Chemistry 280, 27904-27913
McConkey, G.A., Pinney, J.W., Westhead, D.R., Plueckhahn, K., Fitzpatrick, T.B., Macheroux, P. & Kappes, B. Annotating the Plasmodium genome and the enigma of the shikimate pathway (2004) Trends in Parasitology 20, 60-65
Fitzpatrick, T.B., Amrhein, N. & Macheroux, P. Structural and functional impairment of an Old Yellow Enzyme homologue upon affinity tag incorporation (2004) Protein Expression and Purification 36, 280-291
Fitzpatrick, T.B., Amrhein, N. & Macheroux, P. Characterisation of YqjM, an Old Yellow Enzyme homolog from Bacillus subtilis involved in the oxidative stress response (2003) Journal of Biological Chemistry 278, 19891-19897
Fitzpatrick, T.B., Killer, P., Thomas, R. M., Jelesarov, I., Amrhein, N. & Macheroux, P. Chorismate synthase from the hyperthermophile Thermotoga maritima combines thermostability and increased rigidity with catalytic and spectral properties similar to mesophilic counterparts (2001) Journal of Biological Chemistry 276, 18052-18059
Geyer, A., Fitzpatrick, T.B., Pawelek, P., Kitzing, K., Vrielink, A., Ghisla, S. & Macheroux, P. Structure and characterisation of the glycan moiety of L-amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma (2001) European Journal of Biochemistry 268, 4044-4053
Fitzpatrick, T., Ricken, S., Lanzer, M., Amrhein, N. & Macheroux, P., Kappes, B. Subcellular localization and characterization of chorismate synthase in the apicomplexan Plasmodium falciparum (2001) Molecular Microbiology 40, 65-75
O'Sullivan, D.B., O'Connell, T.P., Mahon, M.M., Koenig, A., Milne, J.J., Fitzpatrick, T.B. & Malthouse J.P.G. 13C NMR Study of how the oxyanion pKa values of subtilisin and chymotrypsin tetrahedral adducts are affected by different amino acid residues binding in enzyme subsites S1-S4 (1999) Biochemistry 38, 6187-6194
Fitzpatrick, T.B. & Malthouse, J.P.G. The effect of histidine 228 on the catalytic efficiency and stereospecificity of the serine hydroxymethyltransferase catalysed exchange of the α-protons of amino acids (1998) Biochimica et Biophysica Acta 1386, 220-226
Mahon, M.M., Gramatikova, S.I., Christen, P., Fitzpatrick, T.B. & Malthouse J.P.G. The pyridoxal-5'-phosphate-dependent catalytic antibody 15A9: Its efficiency and stereospecificity in catalysing the exchange of the α-protons of glycine (1998) FEBS Letters 27, 74-784
Fitzpatrick, T.B. & Malthouse, J.P.G. A substrate induced change in the stereospecificity of the serine hydroxymethyltransferase catalysed exchange of the α-protons of amino acids: evidence for a second catalytic site (1998) European Journal of Biochemistry 252, 113-117
Malthouse, J.P.G., Fitzpatrick, T.B., Milne, J.J., Grehn, L. & Ragnarsson, U. Enzymatic synthesis of isotopically labeled serine and tryptophan for application in peptide synthesis (1997) Journal of Peptide Science 3, 361-366
Press Releases
Important piece of jigsaw found. ETH life. 04/12/2007
Wichtiges puzzleteil gefunden. ETH life. 04/12/2007
Now its a question of details. ETH life. 20/03/2007
Nun geht es um die details. ETH life. 20/03/2007
Zahnrad produziert Vitamin B6. ETH life. 11/12/2006
Pflanzen machen es anders. ETH life. 13/10/2005
Neuer Produktionsweg für Vitamin B6. Neue Zürcher Zeitung. 16/11/2005
Book Chapters
Fitzpatrick, T.B., Amrhein, N. & Macheroux, P. Characterisation of an Old Yellow Enzyme homologue from Bacillus subtilis (2002) Flavins and Flavoproteins (edited by Perham, R.N., Chapman S.K. & Scrutton, N.S.) 993-998, Weber (Berlin)
Fitzpatrick, T.B., Amrhein, N. & Macheroux, P. Analysis of a trimeric complex involving chorismate synthase from Bacillus subtilis (1999) Flavins and Flavoproteins (edited by Ghisla, S., Kroneck, P., Macheroux, P. and Sund, H.) 749-752, Weber (Berlin)